Johnson filmed guest roles on Star Trek: Voyager, where he played an alien wrestler that used Johnson's famous moves, and That '70s Show, where he played his father, Rocky Johnson. His motion picture debut was a brief appearance as The Scorpion King in the opening sequence of The Mummy Returns. His character later appears in the climax as a CGI Character. The film's financial success led to his first leading role starring in the follow-up, The Scorpion King. He was considered for the lead in a feature-length Johnny Bravo film, but it was canceled during production.
Since his last WWE match in 2004, he has quit wrestling and focused solely on acting. He also continued to make television appearances, including Disney Channel's hit show Cory in the House, in the episode entitled “Never the Dwayne Shall Meet.” Though Johnson is no longer active with WWE, the company continues to sell "The Rock" merchandise, and Johnson continues to be featured prominently in the opening montages of their television programming. The Rock has continued to show a multitude of his acting/talent skills including film roles like the cocky famous football player Joe Kingman in The Game Plan, and in Get Smart where he played Agent 23.
Johnson was featured in the 2007 Guinness Book of World Records for having the highest salary as an actor in his first starring role, receiving $5.5 million. He appeared at the 80th Academy Awards on February 24, 2008 as a presenter for the Academy Award for Best Visual Effects. He was nominated for Favorite Movie Actor at the 2008 Nickelodeon Kids' Choice Awards for his role in The Game Plan, but lost out to Johnny Depp, who won for his performance in Pirates of the Caribbean: At World's End.
On March 20, 2009, Johnson appeared on The Tonight Show with Jay Leno. Johnson hosted the 2009 Nickelodeon Kids' Choice Awards on March 28. Johnson also appeared on the Wizards of Waverly Place episode "Art Teacher" as part of his stint with The Walt Disney Company.
Johnson has made various guest appearances on Saturday Night Live, reviving his character of The Rock Obama, a parody of The Hulk... "When you make Barack Obama angry, he turns into The Rock Obama."
Johnson also made an uncredited cameo in the 2010 film Tyler Perry's Why Did I Get Married Too? as a handsome psychiatrist who asks out the recently widowed Patricia Agnew (Janet Jackson).
On April 29, 2010, it was announced he will join the cast of Simon West's new film, currently titled Protection. The film is slated for a 2012 release and is scheduled to shoot this fall in New Mexico.